Aisyah Saad Abdul Rahim

BPharm (Cardiff); PhD (Nottingham)

Lecturer

 

Tel: 604-6533888 Ext. 4094

Fax: 604-6570017

Email: aisyah@usm.my

 

Discipline

Pharmaceutical Chemistry

                                                                                                      

Research in carbohydrate-based therapeutics is a young and exciting field; in fact it is the youngest of its two elder sisters i.e. DNA and proteins. In nature, carbohydrates are found linked to biomolecules, and participate in many key biological processes e.g. leukocyte recruitment, viral adhesion and cell signaling.

 

Adhesive and/or communicative intercellular interactions are mainly mediated by cell surface glycoconjugates e.g. glycolipids and glycoproteins/peptides. Still, many functions of glycopeptides/proteins remain unknown due to low availability of such glycoconjugates. 

                                                                                      

Chemical construction of natural glycopeptides/proteins remains the attractive approach since it provides the desired glycopeptides in high purity and good yields. My research interest lies in the area of synthetic carbohydrate medicinal chemistry, particularly the stereoselective construction of natural glycopeptides, either via solution or solid phase synthesis. I am also interested in exploring a number of synthetic approaches towards the generation of glycosyl-substituted heterocyclic derivatives, which are designed to serve as anti-inflammatories and/or anticancers.

 

 

Publications

 

Nα-Dmc protected amino acid aglycones: versatile hydrogenolysis stable acceptors for O-glycosylation

Kellam, B.;Ward, P. A.; Abdul Rahim, A. S.; Chhabra, S. R.

Tetrahedron Lett., 2005, 46,1703-1706 

 

Recent Progress in the Design of Selectin Inhibitors

Chhabra, S.R.; Rahim, A.S.A.; Kellam, B.

Mini Rev. Med. Chem., 2003, 3, 679-687